Periplaneta americana Extracts Accelerate Liver Regeneration via a Complex Network of Pathways
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Periplaneta americana Extracts Promote Skin Wound Healing via Nuclear Factor Kappa B Canonical Pathway and Extracellular Signal-Regulated Kinase Signaling
Periplaneta americana extracts (PAEs) exhibit wound healing properties. However, the underlying molecular mechanisms are not well understood. Here, we treated human skin fibroblasts (HSF) with PAE and the proliferation was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The wound healing and transwell migration assays were used to detect cell migration. N...
متن کاملJAK/STAT3 and Smad3 activities are required for the wound healing properties of Periplaneta americana extracts
Periplaneta americana extracts (PAEs) play a crucial role in skin wound healing. However, their molecular effects and signaling pathways in regenerating tissues and cells are not clear. In this study, we refined the PAE from Periplaneta americana to investigate the mechanisms underlying skin wound healing. The human keratinocyte line HaCaT was selected and a mouse model of deep second-degree th...
متن کاملRegeneration, post-embryonic induction and cellular interaction in the eye of Periplaneta americana.
1. The eye grows by the addition of new ommatidia rather than by an increase in size of existing ones. 2. New ommatidia develop as a result of induction of epidermal cells by functional ommatidia. 3. The eye has great regenerative ability, but following removal of the entire eye and the growth zone that surround it regeneration does not occur. 4. Transplanted eye cells or epidermal cells from n...
متن کاملCharacterization of recombinant per a 10 from Periplaneta americana.
Cockroach allergen is a major risk factor for IgE-mediated allergic response and asthma in sensitized individuals. Serine proteases have been identified from various sources and characterized as major allergens. The present study was aimed to express and characterize recombinant allergen Per a 10 (rPer a 10) from Periplaneta americana. rPer a 10 was expressed in Escherichia coli and purified in...
متن کاملOrganization of the giant axons of the cockroach Periplaneta americana.
Several authors have reported the presence of ascending giant fibres (AGF) in the nerve cord of the American cockroach, Periplaneta americana (Pumphrey & Rawdon-Smith, 1937; Roeder, 1948; Hess, 1958). Roeder (1948) presented a scheme showing a synaptic link (in the 6th abdominal ganglion) between the cereal sensory neurones and the AGF, the latter then ascending as continuous fibres to the meta...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2020
ISSN: 1663-9812
DOI: 10.3389/fphar.2020.01174